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Article

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells

9 Nov 2017

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients. Recent evidence indicates that epithelial-to-mesenchymal transition (EMT) of PDAC cells is strictly associated to early metastasization and resistance to...

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PMID: 29120411
DOI: 10.1038/cddis.2017.562

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