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Article

Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression.

Cell death & disease - 2 Feb 2018

Li Linna, Su Ning, Zhou Ting, Zheng Dayong, Wang Zheng, Chen Haoyu, Yuan Shoujun, Li Wenliang

Abstract excerpt

ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple epithelial cell lines, while having different impacts on cell growth in different cell lines....

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Identifiers

PMID: 29396440
DOI: 10.1038/s41419-017-0161-x
PMCID: PMC5833348

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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