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Article

Role for the silencing protein Dot1 in meiotic checkpoint control.

Molecular biology of the cell - 1 Oct 2000

San-Segundo P A, Roeder G S

Abstract excerpt

During the meiotic cell cycle, a surveillance mechanism called the "pachytene checkpoint" ensures proper chromosome segregation by preventing meiotic progression when recombination and chromosome synapsis are defective. The silencing protein Dot1 (also known as Pch1) is required for checkpoint-mediated pachytene arrest of the zip1 and dmc1 mutants of Saccharomyces cerevisiae. In the absence of DOT1, the zip1 and...

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Identifiers

PMID: 11029058
DOI: 10.1091/mbc.11.10.3601
PMCID: PMC15018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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