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Article

AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

7 Oct 2020

Abstract excerpt

The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in cancer by co-option of a regulatory function normally reserved for stem cells. AXL-expressing cells in human mammary epithelial ducts co-expressed markers associated with...

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PMID: 33103086
DOI: 10.1016/j.isci.2020.101649

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