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Article

Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity.

Annals of neurology - 1 Jan 2021

Dulovic-Mahlow Marija, König Inke R, Trinh Joanne, Diaw Sokhna Haissatou, Urban Peter P, Knappe Evelyn, Kuhnke Neele, Ingwersen Lena-Christin, Hinrichs Frauke, Weber Joachim, Kupnicka Patrycja, Balck Alexander, Delcambre Sylvie, Vollbrandt Tillman, Grünewald Anne, Klein Christine, Seibler Philip, Lohmann Katja

Abstract excerpt

OBJECTIVE: Even though genetic predisposition has proven to be an important element in Parkinson's disease (PD) etiology, monozygotic (MZ) twins with PD displayed a concordance rate of only about 20% despite their shared identical genetic background. METHODS: We recruited 5 pairs of MZ twins discordant for idiopathic PD and established skin fibroblast cultures to investigate mitochondrial phenotypes in these...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33094862
DOI: 10.1002/ana.25942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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