Article
Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex.
Human molecular genetics - 4 Feb 2021
Arsenault Jason, Hooper Alexander W M, Gholizadeh Shervin, Kong Tian, Pacey Laura K, Koxhioni Enea, Niibori Yosuke, Eubanks James H, Wang Lu-Yang, Hampson David R
Abstract excerpt
Several X-linked neurodevelopmental disorders including Rett syndrome, induced by mutations in the MECP2 gene, and fragile X syndrome (FXS), caused by mutations in the FMR1 gene, share autism-related features. The mRNA coding for methyl CpG binding protein 2 (MeCP2) has previously been identified as a substrate for the mRNA-binding protein, fragile X mental retardation protein (FMRP), which is silenced in FXS....
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