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Article

Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory.

Scientific reports - 20 Oct 2020

Ryu Hyun-Hee, Kang Minkyung, Hwang Kyoung-Doo, Jang Han Byul, Kim Sang Jeong, Lee Yong-Seok

Abstract excerpt

KRAS mutations are associated with rare cases of neurodevelopmental disorders that can cause intellectual disabilities. Previous studies showed that mice expressing a mutant KRAS have impaired the development and function of GABAergic inhibitory neurons, which may contribute to behavioural deficits in the mutant mice. However, the underlying cellular mechanisms and the role of excitatory neurons in these...

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PMID: 33082413
DOI: 10.1038/s41598-020-74610-y
PMCID: PMC7575532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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