Article
Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies.
Biological psychiatry - 1 Feb 2017
Papale Alessandro, d'Isa Raffaele, Menna Elisabetta, Cerovic Milica, Solari Nicola, Hardingham Neil, Cambiaghi Marco, Cursi Marco, Barbacid Mariano, Leocani Letizia, Fasano Stefania, Matteoli Michela, Brambilla Riccardo
Abstract excerpt
BACKGROUND: Dysregulation of Ras-extracellular signal-related kinase (ERK) signaling gives rise to RASopathies, a class of neurodevelopmental syndromes associated with intellectual disability. Recently, much attention has been directed at models bearing mild forms of RASopathies whose behavioral impairments can be attenuated by inhibiting the Ras-ERK cascade in the adult. Little is known about the brain...
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