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Article

The impact of ARID1A mutation on molecular characteristics in colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2020

Tokunaga Ryuma, Xiu Joanne, Goldberg Richard M, Philip Philip A, Seeber Andreas, Battaglin Francesca, Arai Hiroyuki, Lo Jae Ho, Naseem Madiha, Puccini Alberto, Berger Martin D, Soni Shivani, Zhang Wu, Chen Sting, Hwang Jimmy J, Shields Anthony F, Marshall John L, Baba Hideo, Korn W Michael, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: ARID1A is a key subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex which regulates dynamic repositioning of nucleosomes to repair DNA damage. Only small pilot studies have evaluated the role of ARID1A mutation in colorectal cancer (CRC). The aim of the present study was to explore the potential impact of ARID1A mutation on clinicopathological and molecular characteristics in CRC. METHODS:...

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Identifiers

PMID: 33080474
DOI: 10.1016/j.ejca.2020.09.006
PMCID: PMC8009046

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