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Article

ARID1A mutation is associated with an immunosuppressive microenvironment and poor prognosis in hepatocellular carcinoma: An integrated bioinformatics analysis.

Immunobiology - 1 May 2026

Huang Manxian, Wan Xiaobing, Chen Hong, Wu Juan, Liu Min, Sun Changli

Abstract excerpt

BACKGROUND: Identifying recurrent genetic mutations is crucial for advancing the understanding and treatment of hepatocellular carcinoma (HCC). The chromatin regulator ARID1A is frequently mutated in cancers, but its integrated impact on prognosis and the tumor immune microenvironment (TIME) in HCC is unclear. METHODS: Somatic mutation and transcriptome data from TCGA and ICGC databases were analyzed....

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42139761
DOI: 10.1016/j.imbio.2026.153190

Genes

ARID1A
BTLA
IDO1
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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