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Article

The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells.

Cancer reports (Hoboken, N.J.) - 1 Jan 2022

Kamori Tomohiro, Oki Eiji, Shimada Yoshifumi, Hu Qingjiang, Hisamatsu Yuichi, Ando Koji, Shimokawa Mototsugu, Wakai Toshifumi, Oda Yoshinao, Mori Masaki

Abstract excerpt

BACKGROUND: ARID1A is a component of the SWI/SNF complex, which controls the accessibility of proteins to DNA. ARID1A mutations are frequently observed in colorectal cancers (CRCs) and have been reported to be associated with high mutational burden and tumor PD-L1 expression in vitro. AIM: To clarify the role of ARID1A mutation in CRC. METHOD AND RESULTS: We used next generation sequencing (NGS) and...

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Identifiers

PMID: 34042312
DOI: 10.1002/cnr2.1420
PMCID: PMC8789618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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