Article
Innate neural stem cell heterogeneity determines the patterning of glioma formation in children.
Cancer cell - 10 Jul 2012
Lee Da Yong, Gianino Scott M, Gutmann David H
Abstract excerpt
The concept that gliomas comprise a heterogeneous group of diseases distinguished by their developmental origin raises the intriguing possibility that neural stem cells (NSCs) from different germinal zones have differential capacities to respond to glioma-causing genetic changes. We demonstrate that lateral ventricle subventricular zone NSCs are molecularly and functionally distinct from those of the third...
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