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Article

IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+ /CD44+ Colon cancer stem cells.

Journal of cellular physiology - 1 Apr 2021

Ma Xiaoying, Chen Jingyun, Liu Jiajun, Xu Baixue, Liang Xinyu, Yang Xiaotong, Feng Yun, Liang Xin, Liu Jianwen

Abstract excerpt

In cancer treatment, the most attractive feature of mesenchymal stem cells (MSCs) is it's homing to tumor tissues. MSC is an important part of the "colon cancer stem cell niche", but little research has been done on the tropism of human MSCs toward colon cancer stem cells (CCSCs). In this study, we first compared the effects of three tissue-derived MSCs (bone marrow, adipose tissue, and placenta) in vivo on colon...

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PMID: 33078417
DOI: 10.1002/jcp.30080

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