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Article

Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway.

Cell death & disease - 25 May 2017

Chen Ke, Liu Qianqian, Tsang Lai Ling, Ye Qiao, Chan Hsiao Chang, Sun Yunwei, Jiang Xiaohua

Abstract excerpt

Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) progression and metastasis is controversial. This study was designed to identify the role of inflammation-activated-MSCs in CRC development. Our results show that tumor necrosis factor (TNF)-α-preactivated-hMSCs significantly promote the...

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Source

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Identifiers

PMID: 28542126
DOI: 10.1038/cddis.2017.138
PMCID: PMC5520690

Genes

CCL5
TNF
CCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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