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Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes

26 Oct 2022

Abstract excerpt

Immunohistochemical analysis of mismatch repair (MMR) protein expression is widely used to identify tumors with a deficient MMR (dMMR). MMR proteins (MLH1/PMS2 and MSH2/MSH6) work as functional heterodimers, which usually leads to the loss of expression in only one functional MMR heterodimer. Recently, there have been studies showing the simultaneous loss of immunoexpression in proteins of both heterodimers. Yet,...

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Identifiers

PMID: 36387226
DOI: 10.3389/fonc.2022.1019798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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