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Article

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer.

Diagnostic pathology - 14 Jul 2020

Moreno Esther, Rosa-Rosa Juan M, Caniego-Casas Tamara, Ruz-Caracuel Ignacio, Perna Cristian, Guillén Carmen, Palacios José

Abstract excerpt

BACKGROUND: Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with intact expression of MLH1 and MSH2. CASE PRESENTATION: We review the frequency of this MMRD IHC pattern among 108 colorectal (CRCs) and 35 endometrial cancers in our files with loss of expression...

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Identifiers

PMID: 32664968
DOI: 10.1186/s13000-020-01001-2
PMCID: PMC7362514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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