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Article

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients

1 Jan 2012

Abstract excerpt

BACKGROUND: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed...

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Share to Carcinogens and Genotoxicity Assessment
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PMID: 22980747
DOI: 10.1186/2041-9414-3-6

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