Article
Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B.
Human genomics - 16 Oct 2020
Papadopoulos Petros, Kafasi Athanassia, De Cuyper Iris M, Barroca Vilma, Lewandowski Daniel, Kadri Zahra, Veldthuis Martijn, Berghuis Jeffrey, Gillemans Nynke, Benavente Cuesta Celina María, Grosveld Frank G, van Zwieten Rob, Philipsen Sjaak, Vernet Muriel, Gutiérrez Laura, Patrinos George P
Abstract excerpt
The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal period (γ to β). The γ- to β-globin gene switching mechanism includes suppression of fetal (γ-globin, HbF) and activation of adult (β-globin, HbA) globin gene transcription. In...
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