Article
A unified model of human hemoglobin switching through single-cell genome editing.
Nature communications - 17 Aug 2021
Shen Yong, Verboon Jeffrey M, Zhang Yuannyu, Liu Nan, Kim Yoon Jung, Marglous Samantha, Nandakumar Satish K, Voit Richard A, Fiorini Claudia, Ejaz Ayesha, Basak Anindita, Orkin Stuart H, Xu Jian, Sankaran Vijay G
Abstract excerpt
Key mechanisms of fetal hemoglobin (HbF) regulation and switching have been elucidated through studies of human genetic variation, including mutations in the HBG1/2 promoters, deletions in the β-globin locus, and variation impacting BCL11A. While this has led to substantial insights, there has not been a unified understanding of how these distinct genetically-nominated elements, as well as other key transcription...
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