Article
Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.
Molecular cell - 15 Oct 2020
Yip Hon Yan K, Chee Annabel, Ang Ching-Seng, Shin Sung-Young, Ooms Lisa M, Mohammadi Zainab, Phillips Wayne A, Daly Roger J, Cole Timothy J, Bronson Roderick T, Nguyen Lan K, Tiganis Tony, Hobbs Robin M, McLean Catriona A, Mitchell Christina A, Papa Antonella
Abstract excerpt
The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity remains undefined. Here, using knockin (KI) mice harboring cancer-associated and functionally relevant missense...
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