Article
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2020
McKnight Kevin L, Swanson Karen V, Austgen Kathryn, Richards Cindy, Mitchell Jonathan K, McGivern David R, Fritch Ethan, Johnson John, Remlinger Katja, Magid-Slav Michal, Kapustina Maryna, You Shihyun, Lemon Stanley M
Abstract excerpt
Human rhinoviruses (RVs) are positive-strand RNA viruses that cause respiratory tract disease in children and adults. Here we show that the innate immune signaling protein STING is required for efficient replication of members of two distinct RV species, RV-A and RV-C. The host factor activity of STING was identified in a genome-wide RNA interference (RNAi) screen and confirmed in primary human small airway...
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