Article
Transbuccal delivery of metal complexes of isoniazid as an alternative to overcome antimicrobial resistance problems.
International journal of pharmaceutics - 30 Nov 2020
Kroth Roselene, Cristiano Monteiro Marcio, Conte Julia, Fretes Argenta Debora, Amaral Beatriz Ribeiro, Szpoganicz Bruno, Caon Thiago
Abstract excerpt
In isolated isoniazid (INH)-resistant strains, deletion or mutations in thekatGgene have been identified, which result in loss of catalase-peroxidase activity. This enzyme plays a key role in the activation of this prodrug. As an alternative, the coordination of the INH to metal complexes has been purposed to activate it regardless of enzyme functionality. Although pentacyanido(isoniazid)ferrate(II) complexes...
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