Article
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
European journal of medicinal chemistry - 5 Nov 2023
Chebaiki Mélina, Delfourne Evelyne, Tamhaev Rasoul, Danoun Saïda, Rodriguez Frédéric, Hoffmann Pascal, Grosjean Emeline, Goncalves Fernanda, Azéma-Despeyroux Joëlle, Pál Adrián, Korduláková Jana, Preuilh Nadège, Britton Sébastien, Constant Patricia, Marrakchi Hedia, Maveyraud Laurent, Mourey Lionel, Lherbet Christian
Abstract excerpt
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) affects 10 million people each year and the emergence of resistant TB augurs for a growing incidence. In the last 60 years, only three new drugs were approved for TB treatment, for which resistances are already emerging. Therefore, there is a crucial need for new chemotherapeutic agents capable of eradicating TB. Enzymes belonging to the type II fatty...
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