Article
Characterization of the binding of isoniazid and analogues to Mycobacterium tuberculosis catalase-peroxidase.
Biochemistry - 20 Mar 2007
Zhao Xiangbo, Yu Shengwei, Magliozzo Richard S
Abstract excerpt
The first-line antituberculosis drug isonicotinic hydrazide (INH) is a prodrug whose bactericidal function requires activation by Mycobacterium tuberculosis catalase-peroxidase (KatG) to produce an acyl-NAD adduct. Peroxidation of INH is considered a required catalytic process for drug action. The binding of INH and a series of hydrazide analogues to resting KatG was examined using optical and calorimetric...
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