Article
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Chemical communications (Cambridge, England) - 7 Feb 2004
Oliveira Jaim S, Sousa Eduardo H S, Basso Luiz A, Palaci Moisés, Dietze Reynaldo, Santos Diógenes S, Moreira Icaro S
Abstract excerpt
The in vitro kinetics of inactivation of both wild-type and I21V InhA enzymes by [FeII(CN)5(INH)]3- indicate that this process requires no activation by KatG, and no need for the presence of NADH. This inorganic complex may represent a new class of lead compounds to the development of anti-tubercular agents aiming at inhibition of a validated target.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.