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Article

The tuberculosis prodrug isoniazid bound to activating peroxidases.

The Journal of biological chemistry - 7 Mar 2008

Metcalfe Clive, Macdonald Isabel K, Murphy Emma J, Brown Katherine A, Raven Emma Lloyd, Moody Peter C E

Abstract excerpt

Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium tuberculosis but the mechanism of activation is poorly understood, in part because the binding interaction has not been properly established. The class I peroxidases ascorbate peroxidase (APX) and...

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Identifiers

PMID: 18056997
DOI: 10.1074/jbc.M707412200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tuberculosis prodrug isoniazid bound to activating peroxidases.PMID 18056997Read ↗

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