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Article

Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling.

Cell host & microbe - 9 Dec 2020

Mahdi Lisa K, Huang Menghang, Zhang Xiaoxiao, Nakano Ryohei Thomas, Kopp Leïla Brulé, Saur Isabel M L, Jacob Florence, Kovacova Viera, Lapin Dmitry, Parker Jane E, Murphy James M, Hofmann Kay, Schulze-Lefert Paul, Chai Jijie, Maekawa Takaki

Abstract excerpt

HeLo domain-containing mixed lineage kinase domain-like protein (MLKL), a pseudokinase, mediates necroptotic cell death in animals. Here, we report the discovery of a conserved protein family across seed plants that structurally resembles vertebrate MLKL. The Arabidopsis genome encodes three MLKLs (AtMLKLs) with overlapping functions in disease resistance mediated by Toll-interleukin 1-receptor domain...

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Identifiers

PMID: 33053377
DOI: 10.1016/j.chom.2020.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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