The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy.

doi:10.3390/ijms21207466

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Article

The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy.

International journal of molecular sciences - 10 Oct 2020

Raucci Frank J, Singh Anand Prakash, Soslow Jonathan, Markham Larry W, Zhong Lin, Aljafar Wejdan, Lessiohadi Natasja, Awgulewitsch Cassandra P, Umbarkar Prachi, Zhang Qinkun, Cannon Presley L, Buchowski Maciej, Roland Joseph T, Carrier Erica J, Burnette William B, Hatzopoulos Antonis K, Lal Hind, Galindo Cristi L

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is a neuronal growth and survival factor that harbors cardioprotective qualities that may attenuate dilated cardiomyopathy. In ~30% of the population, BDNF has a common, nonsynonymous single nucleotide polymorphism rs6265 (Val66Met), which might be correlated with increased risk of cardiovascular events. We previously showed that BDNF correlates with better cardiac...

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PMID: 33050457
DOI: 10.3390/ijms21207466
PMCID: PMC7593910

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