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Article

Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy.

Scientific reports - 12 Oct 2020

Sugihara Hidetoshi, Teramoto Naomi, Nakamura Katsuyuki, Shiga Takanori, Shirakawa Taku, Matsuo Masafumi, Ogasawara Masashi, Nishino Ichizo, Matsuwaki Takashi, Nishihara Masugi, Yamanouchi Keitaro

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a progressive disease characterised by chronic muscle degeneration and inflammation. Our previously established DMD model rats (DMD rats) have a more severe disease phenotype than the broadly used mouse model. We aimed to investigate the role of senescence in DMD using DMD rats and patients. Senescence was induced in satellite cells and mesenchymal progenitor cells, owing to...

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Identifiers

PMID: 33046751
DOI: 10.1038/s41598-020-73315-6
PMCID: PMC7550355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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