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Article

The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy

12 Feb 2015

Abstract excerpt

Although it has been speculated that stem cell depletion plays a role in the rapid progression of the muscle histopathology associated with Duchenne Muscular Dystrophy (DMD), the molecular and cellular mechanisms responsible for stem cell depletion remain poorly understood. The rapid depletion of muscle stem cells has not been observed in the dystrophin-deficient model of DMD (mdx mouse), which may explain the...

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PMID: 25678553
DOI: 10.1093/hmg/ddv055

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