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Article

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche.

Journal of translational medicine - 27 Jan 2015

Ghiabi Pegah, Jiang Jie, Pasquier Jennifer, Maleki Mahtab, Abu-Kaoud Nadine, Halabi Najeeb, Guerrouahen Bella S, Rafii Shahin, Rafii Arash

Abstract excerpt

BACKGROUND: Endothelial cells (ECs) are responsible for creating a tumor vascular niche as well as producing angiocrine factors. ECs demonstrate functional and phenotypic heterogeneity when located under different microenvironments. Here, we describe a tumor-stimulated mesenchymal phenotype in EC...

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Source

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Identifiers

PMID: 25623554
DOI: 10.1186/s12967-015-0386-3
PMCID: PMC4336716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25623554-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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