Article
Targeted Sequencing of Circulating Tumor DNA to Monitor Genetic Variants and Therapeutic Response in Metastatic Colorectal Cancer.
Molecular cancer therapeutics - 1 Oct 2018
Hsu Hung-Chih, Lapke Nina, Wang Chuang-Wei, Lin Pei-Yi, You Jeng Fu, Yeh Chien Yuh, Tsai Wen-Sy, Hung Hsin Yuan, Chiang Sum-Fu, Chen Hua-Chien, Chen Shu-Jen, Hsu An, Yang Tsai Sheng
Abstract excerpt
Substantial improvements have been made in the management of metastatic colorectal cancer (mCRC) in the last two decades, but disease monitoring remains underdeveloped. Circulating tumor DNA (ctDNA) is a promising prognostic and predictive biomarker; however, ctDNA as a marker for mCRC patients is not well established, and there is still no consensus about how to utilize it most cost-effectively. In this study,...
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