Article
Interaction between susceptibility loci in cGAS-STING pathway, MHC gene and HPV infection on the risk of cervical precancerous lesions in Chinese population.
Oncotarget - 20 Dec 2016
Xiao Di, Huang Weihuang, Ou Meiling, Guo Congcong, Ye Xingguang, Liu Yang, Wang Man, Zhang Baohuan, Zhang Na, Huang Shiqi, Zang Jiankun, Zhou Zixing, Wen Zihao, Zeng Chengli, Wu Chenfei, Huang Chuican, Wei Xiangcai, Yang Guang, Jing Chunxia
Abstract excerpt
Human papillomavirus (HPV) infection is a definite risk factor for cervical cancer. Nevertheless, only some infected individuals actually develop cervical cancer. The cGAS-STING pathway in innate immunity plays an important role in protecting against HPV infection. Chen et al. described that the rs2516448 SNP in the MHC locus may affect susceptibility to cervical cancer, a finding that we attempted to replicate...
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