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Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis

8 Feb 2023

Abstract excerpt

Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics to characterize all major liver cell types during NASH development in mice and humans. The bifurcation of hepatocyte trajectory with NASH progression was conserved...

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PMID: 36753562
DOI: 10.1126/scitranslmed.adc9653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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