Article
Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease.
PLoS genetics - 1 Mar 2020
Ferreira Nicola, Andoniou Christopher E, Perks Kara L, Ermer Judith A, Rudler Danielle L, Rossetti Giulia, Periyakaruppiah Ambika, Wong Jamie K Y, Rackham Oliver, Noakes Peter G, Degli-Esposti Mariapia A, Filipovska Aleksandra
Abstract excerpt
The influence of environmental insults on the onset and progression of mitochondrial diseases is unknown. To evaluate the effects of infection on mitochondrial disease we used a mouse model of Leigh Syndrome, where a missense mutation in the Taco1 gene results in the loss of the translation activator of cytochrome c oxidase subunit I (TACO1) protein. The mutation leads to an isolated complex IV deficiency that...
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