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Article

Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.

Mitochondrion - 1 Jan 2011

Cannon M V, Dunn D A, Irwin M H, Brooks A I, Bartol F F, Trounce I A, Pinkert C A

Abstract excerpt

Xenomitochondrial mice, harboring evolutionarily divergent Mus terricolor mitochondrial DNA (mtDNA) on a Mus musculus domesticus nuclear background (B6NTac(129S6)-mt(M. terricolor)/Capt; line D7), were subjected to molecular and phenotypic analyses. No overt in vivo phenotype was identified in contrast to in vitro xenomitochondrial cybrid studies. Microarray analyses revealed differentially expressed genes in...

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Identifiers

PMID: 20638486
DOI: 10.1016/j.mito.2010.07.003
PMCID: PMC3005533

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