Article
Individuals with HIV-1 Subtype C Infection and Cryptococcal Meningitis Exhibit Viral Genetic Intermixing of HIV-1 Between Plasma and Cerebrospinal Fluid and a High Prevalence of CXCR4-Using Variants.
AIDS research and human retroviruses - 1 Jul 2018
Sojane Katlego, Kangethe Richard T, Chang Christina C, Moosa Mahomed-Yunus S, Lewin Sharon R, French Martyn A, Ndung'u Thumbi
Abstract excerpt
The genotypic properties of human immunodeficiency virus type 1 (HIV-1) subtype C in individuals presenting with cryptococcal meningitis (CM) are not well established. Employing single-genome amplification as well as bulk PCR, cloning and sequencing strategies, we evaluated the genetic properties of HIV-1 subtype C env in 16 antiretroviral therapy-naive study participants with CM. Eleven of the 16 participants...
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