Article
HIV-1C env and gag Variation in the Cerebrospinal Fluid and Plasma of Patients with HIV-Associated Cryptococcal Meningitis in Botswana.
Viruses - 7 Dec 2020
Kelentse Nametso, Moyo Sikhulile, Mogwele Mompati L, Ditshwanelo Doreen, Mokaleng Baitshepi, Moraka Natasha O, Lechiile Kwana, Leeme Tshepo B, Lawrence David S, Musonda Rosemary, Kasvosve Ishmael, Harrison Thomas S, Jarvis Joseph N, Gaseitsiwe Simani
Abstract excerpt
HIV-1 compartmentalization in reservoir sites remains a barrier to complete HIV eradication. It is unclear whether there is variation in HIV-1 env and gag between cerebrospinal fluid (CSF) and plasma of individuals with HIV-associated cryptococcal meningitis (CM). We compared HIV-1 env characteristics and the gag cytotoxic T-lymphocyte (CTL) escape mutations from CSF and plasma samples. Employing population-based...
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