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Article

HIV-1 drug resistance mutations among individuals with low-level viraemia while taking combination ART in Botswana.

The Journal of antimicrobial chemotherapy - 27 Apr 2022

Bareng Ontlametse T, Moyo Sikhulile, Zahralban-Steele Melissa, Maruapula Dorcas, Ditlhako Tsotlhe, Mokaleng Baitshepi, Mokgethi Patrick, Choga Wonderful T, Moraka Natasha O, Pretorius-Holme Molly, Mine Madisa O, Raizes Elliot, Molebatsi Kesaobaka, Motswaledi Modisa S, Gobe Irene, Mohammed Terence, Gaolathe Tendani, Shapiro Roger, Mmalane Mompati, Makhema Joseph M, Lockman Shahin, Essex Max, Novitsky Vlad, Gaseitsiwe Simani

Abstract excerpt

OBJECTIVES: To assess whether a single instance of low-level viraemia (LLV) is associated with the presence of drug resistance mutations (DRMs) and predicts subsequent virological failure (VF) in adults receiving ART in 30 communities participating in the Botswana Combination Prevention Project. METHODS: A total of 6078 HIV-1 C pol sequences were generated and analysed using the Stanford HIV drug resistance...

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Anti-HIV Agents
Botswana
Drug Resistance
Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Seropositivity

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PMID: 35229102
DOI: 10.1093/jac/dkac056
PMCID: PMC9633723

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