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Thymidylate synthase inhibitors for non-small cell lung cancer

9 Sept 2011

Abstract excerpt

INTRODUCTION: The folate-dependent enzyme thymidylate synthase (TS) plays a pivotal role in DNA replication/repair and cancer cell proliferation, and represents a valid target for the treatment of several tumor types, including NSCLC. NSCLC is the leading cause of cancer-related mortality, and several TS inhibitors have gone into preclinical and clinical testing, with pemetrexed emerging for its approval and...

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PMID: 21905922
DOI: 10.1517/13543784.2011.617742

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