Article
Host pre-conditioning improves human adipose-derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome.
Journal of cellular and molecular medicine - 1 Nov 2020
Lee Tsung-Ming, Harn Horng-Jyh, Chiou Tzyy-Wen, Chuang Ming-Hsi, Chen Chun-Hung, Chuang Chi-Hsuan, Lin Po-Cheng, Lin Shinn-Zong
Abstract excerpt
Functional decline of stem cell transplantation in ageing hosts is well documented. The mechanism for this is poorly understood, although it is known that advancing age does not provide an optimal milieu for exogenous stem cells to survive, engraft and differentiate. We showed that n-butylidenephthalide improved human adipose-derived stem cell (hADSC) engraftment via attenuating the production of reactive oxygen...
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