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Article

Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.

Cardiovascular research - 1 Feb 2019

Zhao Meng, Fan Chengming, Ernst Patrick J, Tang Yawen, Zhu Hanxi, Mattapally Saidulu, Oduk Yasin, Borovjagin Anton V, Zhou Lufang, Zhang Jianyi, Zhu Wuqiang

Abstract excerpt

Aims: The effectiveness of cell-based treatments for regenerative myocardial therapy is limited by low rates of cell engraftment. Y-27632 inhibits Rho-associated protein kinase (ROCK), which regulates the cytoskeletal changes associated with cell adhesion, and has been used to protect cultured cells during their passaging. Here, we investigated whether preconditioning of cardiomyocytes, derived from human-induced...

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Identifiers

PMID: 30107391
DOI: 10.1093/cvr/cvy207
PMCID: PMC6341224

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