Article
Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells.
Journal of molecular and cellular cardiology - 1 Mar 2017
Lee Tsung-Ming, Harn Horng-Jyh, Chiou Tzyy-Wen, Chuang Ming-Hsi, Chen Chun-Hung, Lin Po-Cheng, Lin Shinn-Zong
Abstract excerpt
Adipose-derived stem cell (ADSC) transplantation is a promising new therapy to improve cardiac function after myocardial infarction. However, its low efficacy of transdifferentiation hampers its usefulness. Glycogen synthase kinase-3β (GSK-3β) signal has been shown to play a role in preconditioning-induced cardioprotection. We assessed whether n-butylidenephthalide (BP) primed ADSCs can attenuate arrhythmias by a...
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