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Inducing Oxidative Stress-Driven Senescent Phenotype in Induced Pluripotent Stem Cell Derived Cardiomyocytes.

Cell biochemistry and biophysics - 1 Dec 2025

Emanet Hatice, DiPietro Frances, Philip Sneha, Acun Aylin

Abstract excerpt

Cardiovascular diseases (CVDs) pose a significant health challenge, particularly among aging populations. Age-related cellular transformations, such as apoptosis, fibrosis, and senescence, contribute to CVDs, necessitating a deeper understanding of cellular aging mechanisms. While animal models offer insights, their translational relevance remains limited, underscoring the need for human-based models. Induced...

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PMID: 40824472
DOI: 10.1007/s12013-025-01854-8

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