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Article

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction

1 Feb 2018

Abstract excerpt

Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown. To examine this, RNU rats received intramyocardial injection of 1 × 10 7 NHP or human iPSC-CMs or the same number of respective fibroblasts or PBS control (n =...

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PMID: 29398480
DOI: 10.1016/j.stemcr.2018.01.002

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