Article
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Neuron - 25 Nov 2020
Nguyen Lien, Laboissonniere Lauren A, Guo Shu, Pilotto Federica, Scheidegger Olivier, Oestmann Angelina, Hammond Jennetta W, Li Herman, Hyysalo Anu, Peltola Roosa, Pattamatta Amrutha, Zu Tao, Voutilainen Merja H, Gelbard Harris A, Saxena Smita, Ranum Laura P W
Abstract excerpt
Mordes et al. (2020) did not detect the survival or motor phenotypes in C9orf72 BAC transgenic mice originally described by Liu et al. (2016). We discuss methodological differences between the Mordes and Liu studies, several additional studies in which survival and motor phenotypes were found, and possible environmental and genetic effects. First, Nguyen et al. (2020) showed robust ALS/FTD phenotypes in C9-BAC...
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