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Article

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.

Neuron - 25 Nov 2020

Mordes Daniel A, Morrison Brett M, Ament Xanthe H, Cantrell Christopher, Mok Joanie, Eggan Pierce, Xue Carolyn, Wang Jin-Yuan, Eggan Kevin, Rothstein Jeffrey D

Abstract excerpt

A hexanucleotide repeat expansion at C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Initial studies of bacterial artificial chromosome (BAC) transgenic mice harboring this expansion described an absence of motor and survival phenotypes. However, a recent study by Liu and colleagues described transgenic mice harboring a large repeat expansion (C9-500)...

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Identifiers

PMID: 33022228
DOI: 10.1016/j.neuron.2020.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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