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Article

A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests 'space cadet syndrome' on two FVB backgrounds.

Disease models & mechanisms - 1 Feb 2025

Badger Sophie E, Coldicott Ian, Kyrgiou-Balli Ergita, Higginbottom Adrian, Moutin Chloé, Mohd Imran Kamallia, Day John C, Cooper-Knock Johnathan, Mead Richard J, Alix James J P

Abstract excerpt

C9orf72-related amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) has proven difficult to model in mice. Liu et al. (2016) reported a bacterial artificial chromosome (BAC) transgenic mouse displaying behavioural, motor and pathological abnormalities. This was followed by multiple laboratories independently refuting and confirming phenotypes. A proposed explanation centred on the use of different...

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Identifiers

PMID: 39945358
DOI: 10.1242/dmm.052221
PMCID: PMC11849976

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