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Article

Co-evolution of MHC class I and variable NK cell receptors in placental mammals.

Immunological reviews - 1 Sept 2015

Guethlein Lisbeth A, Norman Paul J, Hilton Hugo G, Parham Peter

Abstract excerpt

Shaping natural killer (NK) cell functions in human immunity and reproduction are diverse killer cell immunoglobulin-like receptors (KIRs) that recognize polymorphic MHC class I determinants. A survey of placental mammals suggests that KIRs serve as variable NK cell receptors only in certain primates and artiodactyls. Divergence of the functional and variable KIRs in primates and artiodactyls predates placental...

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Share to Mammals
Share to Phylogeny
Share to Receptors, KIR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetic Variation

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

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Source

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Identifiers

PMID: 26284483
DOI: 10.1111/imr.12326
PMCID: PMC4587382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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