Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2020

Franchi Federico, Peterson Karen M, Quandt Katherine, Domnick David, Kline Timothy L, Olthoff Michaela, Parvizi Mojtaba, Tolosa Ezequiel J, Torres Vicente E, Harris Peter C, Fernandez-Zapico Martin E, Rodriguez-Porcel Martin G

Abstract excerpt

Polycystic kidney disease (PKD) has been linked to abnormal structure/function of ciliary proteins, leading to renal dysfunction. Recently, attention has been focused in the significant vascular abnormalities associated with PKD, but the mechanisms underlying this phenomenon remain elusive. Here, we seek to define the molecular events regulating the angiogenic imbalance observed in PKD. Using micro computed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Polycystic Kidney Diseases

Share to X-Ray Microtomography

Share to Zinc Finger Protein GLI1

Source

Open in PubMed Open full text

Identifiers

PMID: 33012205
DOI: 10.1161/HYPERTENSIONAHA.120.15483
PMCID: PMC7666088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.PMID 33012205Read ↗

Global Transcriptomics of Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease using PCK ratsSemantic proximity Read ↗

Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model.Semantic proximity Read ↗

Polycystin 1 is required for the structural integrity of blood vessels.Semantic proximity Read ↗

Clinical findings, underlying pathogenetic processes and treatment of vascular dysfunction in autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.Semantic proximity Read ↗

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.Semantic proximity Read ↗

Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.Semantic proximity Read ↗

Reversal of elevated <i>Gli3</i> in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesisSemantic proximity Read ↗

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.Semantic proximity Read ↗

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic DevelopmentSemantic proximity Read ↗

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney diseaseSemantic proximity Read ↗

ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.